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In regard to DPI, we previously demonstrated that low micromolar concentrations effectively reduced tumor growth and metastasis in a MYCN-driven zebrafish model of NB, with low associated toxicity (16)

It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)

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These can include pain or redness at the injection site, mild diarrhea, and a feeling of swelling over the entire body [1]

Base-calling of automated sequencer traces using phred