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Mitochondrial dysfunction and ROS production can damage the ER, triggering further stress responses ( 3.3 Lysosomal: iron release and autophagic regulation Lysosomes are key organelles for degradation, recycling, and metabolic regulation ( Lysosomes are central to iron metabolism through ferritin degradation ( 3.4 Lipid droplets: lipid storage and release in axis fueling Lipid droplets (LDs) are dynamic organelles storing neutral lipids, playing key roles in energy homeostasis and lipid metabolism ( LDs also modulate cellular redox status by sequestering ROS and providing a controlled environment for lipid peroxidation ( Notably, LDs cooperate with peroxisomes to regulate PUFA metabolism

Samples were analyzed in a randomized fashion

The lack of multi-drug delivery platforms and long-term stability further restricts the clinical utility of PLGA nanosystems

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4.4 Obesity-associated airway smooth muscle remodeling in asthma Pathological changes in ASM remodeling include both hypertrophy (an increase in muscle mass) and hyperplasia (an increase in the number of ASM cells) (254)