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7.1.3 mTOR inhibitors The mTOR inhibitors are the most extensively studied targeted therapies for the PI3K-AKT-mTOR signaling pathway and were the first to enter clinical practice (233)

ROS-induced cell death Increased ROS levels can trigger cell cycle arrest, cellular senescence, and the death of cancer cells (Ichijo et al

Cons The supplement may not be suitable for people with certain medical conditions or those who are taking certain medications

Start: 2 mg weekly for 4 weeks to assess tolerance [6]

Cimmino, G

They are signaling molecules that instruct other molecules and cells on the functions they should perform