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The results suggest impaired insulin response to high glucose levels in PD, which may be due to the failure of cells to enhance insulin secretion to cope with elevated blood glucose

Although HIFs are the canonical substrates for PHD- and FIH-mediated protein hydroxylation, increasing evidence indicates that these hydroxylases may also have alternative targets

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Collectively, these studies establish histone acetylation as a fundamental epigenetic mechanism sustaining glioma stem cell properties via dynamic crosstalk with histone methylation, ubiquitination, and other post-translational modifications, and highlight acetylation-centered regulatory networks as promising therapeutic vulnerabilities in GBM

Because of this, it means you do not store them in large amounts and need to consume some from your diet everyday

Nat Med (2014) 20(11):132733