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Critics further worry that the regulatory change is a fait accompli, no matter the lack of evidence

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The catalytic and regulatory loops of GS were highly conserved, which included the Glu loop (flap, PGY E 337 AP), Asp loop (latch, D 60 D 74 ), Asn loop (residues F 265 N 274 ), Tyr loop (S 163 Y 190 M 199 ), and adenylation loop (NL F 407 KLT) 9,12 (Fig

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