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Without B12, the production of red blood cells can decrease, impairing oxygen delivery

Funnel plot asymmetry and Eggers tests suggested potential small-study effects in some datasets (HDRS, BDI), raising concerns about publication bias

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Pc target genes in cluster including DN1s and LNds may be less relevant to circadian rhythms

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Participants also showed better social interaction and communication during treatment periods, with effects that tended to revert after stopping therapy