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Upon binding to growth factors, these receptor tyrosine kinases are activated through dimerization and phosphorylation, which trigger the activation of three intracellular protein cascades: the RAS/RAF/MAPK (ERK) pathway, P13K/AKT pathway and PLC-/PKC pathway

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We look forward to seeing further results as this may suggest a path forward for semaglutide as part of a combination therapy approach. 5

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