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Efficacy: 66.2% are still alive

Li M, Konteatis Z, Nagaraja N et al (2022) Leveraging structure-based drug design to identify next-generation MAT2A inhibitors, including brain-penetrant and peripherally efficacious leads

Salt-inducible kinase 2 (SIK2) overexpression in ovarian cancer cells activates the PI3K/AKT/HIF-1 pathway, upregulates HIF-1 expression, directly upregulates the transcription of major glycolytic genes and promotes glycolysis (123)

Biochimica et Biophysica Acta (BBA)-Bioenergetics

Moreover, certain cancer cells enter a state of quiescent growth during the treatment process, known as drug-tolerant persister (DTP), which allows them to evade the apoptosis induced by chemotherapy and targeted therapy [130]

The relative efficacy of GPi-DBS for improving tardive dystonia of different body parts and the temporal course of improvement were assessed in 8 patients in another study [160]