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In recent years, many key molecular mechanisms of ferroptosis have been identified, including GPX4-GSH, ferroptosis-suppressor-protein 1 (FSP1)-CoQ 10 , GTP cyclohydrolase 1 (GCH1)-tetrahydrobiopterin (BH 4 ), dihydroorotate dehydrogenase (DHODH)-CoQ, and FSP1-vitamin K (VK)[8, 17-19] (Figure 1)

The K-means clustering algorithm divided 4126 DEPs (differentially expressed proteins) of the whole groups into 6 clusters, which was consistent with heatmap results

All three of these factors work together

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Individuals with moderate glutathione synthetase deficiency may experience symptoms beginning shortly after birth including hemolytic anemia, 5-oxoprolinuria, and elevated acidity in the blood and tissues (metabolic acidosis)

CGD may be caused by variants affecting the core protein gp91 phox (encoded by CYBB ) or one of its subunits ( CYBA , CYBC1 , NCF1 , NCF2 and NCF4 )