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In neurodegenerative diseases, including Alzheimers disease (AD), Parkinsons disease (PD), and amyotrophic lateral sclerosis (ALS), pro-inflammatory cytokines such as TNF- and IL-1 released by activated microglia upregulate neuronal iron transporters (e.g., DMT1 and TfR1), promoting iron accumulation and ferroptotic cell death

Our experiments have elucidated a coordinated mechanism underlying this phenomenon, characterized by the rapid induction of ISR and oxidative stress response (OSR), accompanied by increased GDF15 and FGF21, and a reduction in CoA levels resulting in metabolic inefficiency, therefore offering insights for potential intervention in metabolic diseases and body-weight control

GABAergic interneurons in epilepsy: more than a simple change in inhibition

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Poly lactic-co-glycolic acid (PLGA) nanoparticles From its original use in surgical sutures to its current use in advanced drug delivery systems, PLGA is a prominent biodegradable polymer whose development reflects decades of innovation in biomaterials research

But occasional high doses (4,000mg+) may still carry risks