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Mahoney, D.J

Gastrointestinal distress affects roughly 28% of users at higher doses, with nausea being the most commonly reported complaint

Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with TRAF3 mutations

Notably, the crystal structure revealed that the G-loop gate and inner helix gate are too constricted to conduct hydrated K + ions, suggesting the channel in the presence of PIP 2 is closed in this structure (Whorton and MacKinnon, 2011)

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