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In the genetic models of obesity, mice carrying inactivation mutation in the leptin receptor (so-called db/db mice) and in Zucker rats, PKC deficiency prevents hepatic triglyceride accumulation [65, 66], promotes insulin signaling by restoring AKT as well as glycogen synthases kinase (GSK3) activity and induces glucose uptake [65, 67]

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- poate contribui la eficientizarea proceselor metabolice

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39 Isoniazid, a first-line anti-tuberculosis drug, is associated with hepatotoxicity, which significantly limits its clinical application

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