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Interestingly, the study also noted striking sex-based differences

However, it can only be synthesized by some bacteria and archaea, thus, animals have to obtain it through their diet

2022 Nov 2;110(21):3458-3483

Hunter R, Wilson T, Lucas S, Scieszka D, Bleske B, Ottens A, et al

Additionally, betaine supplementation can increase the levels of fibroblast growth factor 21 (FGF21) in the liver and circulation, enhance white fat oxidation capacity and whole-body energy expenditure, thereby enhancing blood glucose homeostasis and metabolic health (79, 83, 85)