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doi: 10.1111/ele.12482

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Comprising a short chain of nine amino acids, DSIP is recognized for its role in modulating sleep-wake cycles, neuroendocrine function, and stress responses

Effects on skin of Stichopus japonicus viscera extracts detected with saponin including holothurin A: Down-regulation of melanin synthesis and Up-regulation of neocollagenesis mediated by ERK signaling pathway

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The latter peculiar feature may be adopted for drug delivery applications since the release can be modulated and programmed by a specific pH stimulus