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However, the immune response of the CNS is complex and involves a myriad of diverse cell populations such as astrocytes, microglia, macrophages, NK cells, and T and B cells (Aoyama, 2021)

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The cyanide can become detached from the sugar after ingestion and must be detoxified, usually by the enzyme rhodanese, which converts cyanide to thiocyanate, which is then excreted in the urine

some respond strongly at lower doses, while others report minimal benefit