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Along with complimenting each other, the combination also leads to reduced drug resistance which is generally seen with monotherapy [260, 261]

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The t-butyl ester is resistant to plasma esterases

Pemetrexed injection is also used together with cisplatin as the first treatment of malignant pleural mesothelioma (cancer that affects the inside lining of the lungs and chest wall) that cannot be removed by surgery