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doi: 10.1016/j.yfrne.2021.100913 123 Rodriguez-ChavezVMoranJMolina-SalinasGZepeda RuizWARodriguezMCPicazoOet al

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This complex activity imbalance leads to ROS generation in both mitochondrial matrix and cytosol, which results in glutathione depletion and increased lipid peroxidation