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Furthermore, research predominantly focuses on single phytochemicals or derivatives (eg, salidroside, 100,126 sodium tanshinone IIA sulfonate, 84,85 resveratrol, 93,133,134 astragaloside IV 92,123,124 ), whose mechanisms are relatively tractable, yet this contrasts sharply with clinical practice utilizing complex traditional Chinese medicine (TCM) formulas (eg, Tongxinluo 41,42 or Qili Qiangxin Capsule 44 )

Neutralizing free radicals that cause cell damage

44 Galindo-MndezM.Navarrete-SalazarH.Baltazar-JimnezF.Muoz-de la PazE.Snchez-MawcinittM

If the endpoint was reached, mice were terminated by cervical dislocation or CO 2 gas chamber

It strengthens the immune system

J Ethnopharmacol 129(3):344349 Sharma A, Kamble SH, Len F, Chear NJY, King TI, Berthold EC et al (2019) Simultaneous quantification of ten key Kratom alkaloids in Mitragyna speciosa leaf extracts and commercial products by ultra-performance liquid chromatographytandem mass spectrometry