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In the early stage, a large number of studies focused on tumor cells, but with the continuous understanding of tumor structure, TME has been proved to play a key role in the process of tumor occurrence, development, metastasis, drug resistance, and the acquisition and maintenance of tumor characteristics depend on the role of TME to varying degrees (11, 12)

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Under pathological conditions such as oxidative stress, hyperactivation of PARP-1 significantly promotes the accumulation of -syn (Puentes et al., 2021)

Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetis J