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Key finding: AOD 9604 (0.1-10 mcg/kg) promoted cartilage repair with 52% defect filling versus 8% in controls

IF is degraded by lysosomes, freeing up vitamin B12, which is released into the cytoplasm, traveling into the portal circulation either bound to transcobalamin to be transported to the tissue or haptocorrin to be transported to the liver

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This interaction has been reported with a combination product of hydrochlorothiazide and triamterene

But you've reduced effective dose by nearly half through timing alone

Figure 7.13 Partially damaged endothelial cells with thrombosis is seen 8 hours after injection of polidocanol 0.25% in the rabbit ear vein (hematoxylineosin, 40)