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The formulation and dosage regimens of B12 used to treat Vitamin B12 deficiency vary widely depending on the aetiology of the deficiency as well as region of medical practice (Table 2)

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At the cellular level, capsaicin downregulates lipogenic genes including SREBP-1c, FAS, and ACC, while upregulating lipid oxidationrelated genes such as PPAR and PPAR in hepatocytes (12, 45)