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In fact, a 2019 study found that both oral glutathione (500 mg/day) and topical 2.0% oxidized glutathione helped brighten skin tone in sun-exposed areas by reducing the melanin index

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Additionally, RT-qPCR analysis indicated that the mRNA expressions of CD206, interleukin-10 (IL-10), and arginase-1 (Arg-1), commonly recognized markers of M2-like macrophages, were significantly upregulated among all SP treatment groups (Fig