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It has been reported that matrix metalloprotease (MMP) enzymes are responsible for the proteolytic degradation of ECM, and they play a role in invasion and metastasis due to the high expression of these MMPs in various tumor tissues (Kleiner and Stetler-Stevenson 1999)

141,142 In summary, the medical treatment of presumed cocaine-associated myocardial ischemia should begin with the sequential treatment of oxygen, benzodiazepines, nitroglycerin, and aspirin as the diagnostic investigation is underway