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Scorletti E, Afolabi PR, Miles EA, et al

Vesicular glutamate transporters 1 and 2 target to functionally distinct synaptic release sites

As organisms age, these cells become senescent (dormant) and less capable of repairing damage

Consequently, when the FRDA fibroblasts were lifted and allowed to settle, there was decreased spreading, indicating deficient contractility and motility due to this cytoskeletal disarrangement ( In relation to the previously described alterations to mitochondrial function in FRDA, mitochondrial transport along neuronal axons and dendrites is mediated by interactions with cytoskeletal microtubules and neurofilament illustrating a key link between actin, mitochondrial function, and neuronal homeostasis (Sparaco et al., 2009

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