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Description

Characterization of in vitro metabolites of isoxazole 2 Isoxazole 2 was incubated with mouse and human microsomes as described above, except the concentration was increased to 10 M to facilitate detection of metabolites, and the final supernatant was filtered through a 0.2-micron PVDF syringe filter prior to analysis by LC-TOF/MS (Sciex 6600 QTOF running Analyst TF 1.8.1)