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The protein concentration was determined using a bicinchoninic acid protein assay kit (Beyotime, Shanghai, China)

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Further study is needed to characterize adduct profiles in patients receiving low doses of APAP with preexisting disease (e.g., liver disease) to better understand the potential application of this biomarker across a range of APAP exposures

When mitochondrial membrane potential is high, ROS are produced and result in a production of 4-HNE which in turn leads to a decrease in membrane potential via UCPs and ANT (Fig

Research has shown that selenium can mitigate the toxic effects of AFB1 through several mechanisms