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Ensuring biocompatibility and avoiding immune system activation are critical

10.1155/2015/287401 Biomed Res Int

doi: 10.1016/j.celrep.2023.112189

Hyperpigmentation was observed when this compound got oxidized and inactivated by factors such as heat, radiation and inflammation with consequent loss of the inhibitory effect on tyrosinase

In animals studies, BPC-157 has been administered in the following ways: To rats at a dose of 10 mcg/kg via injection [12] To mice at a dose of 10 g or 10 ng/kg body weight intraperitoneally (i.p.) via injection [14] To mice as a thin layer of cream topically (50 g of BPC 157 dissolved in 2 ml of distilled water with 50 g of commercial neutral cream and 1% white silver sulfadiazine)

Biochem Biophys Res Commun 397:608613 Yang M, Dong Y, He Q, Zhu P, Zhuang Q, Shen J, Zhang X, Zhao M (2020) Hydrogen: a novel option in human disease treatment