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Stay well-hydrated and ensure adequate micronutrient intake, particularly vitamin C, zinc, and copper for collagen formation

Aging is accompanied by BBB breakdown, and instead of being region-specific as in neurological diseases (e.g., hippocampus in Alzheimers disease), it is zonation-specific (capillaries are more affected than other vessel types) (Zhao et al., 2020)

They are especially suitable for individuals needing ongoing, maintenance-level doses of B12

These so called cutoffs are derived from serum MMA concentrations compiled from US NHANES 20032006 data in which the central 95% reference intervals (2.5th to 97.5th percentile) for serum MMA concentrations were presented (Pfeiffer et al., 2013)