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Systemic : Inflammation regulation, damage repair, and inter-system communication (e.g., brain, gut, muscles, metabolism)

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Others likely experience no difference

LncRNA TUG1 sponges miR-204-5p to promote osteoblast differentiation through upregulating Runx2 in aortic valve calcification

The addition of a figure would also be great to provide a "big picture" snapshot of where these various cooperative and competitive behavioral effects may be occurring. Response: We appreciate your compliments regarding the paper

10.1016/S0140-6736(23)00441-5 36 KhanA