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As the oxidative burden on the nervous system decreases, the autonomic nervous system can begin to shift back toward parasympathetic dominance (the "rest-and-digest" state)

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2019;17:400 Zohny SM, Habib MZ, Mohamad MI, Elayat WM, Elhossiny RM, El-Salam MFA, et al

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TBI pathology involves primary injury directly induced by biomechanical forces, succeeded by secondary injury mediated by excitotoxicity, calcium dyshomeostasis, oxidative stress, neuroinflammation, and mitochondrial dysfunction (Maas et al., 2017)

Initial treatment focuses on IV fluid replacement (typically 1-2 liters of normal saline) while investigating underlying causes through blood tests and cardiac monitoring