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Un estudio observacional multicntrico, de seis meses, inscribi a 197 sujetos con accidente cerebrovascular (edad promedio, 81.5 aos) con un deterioro progresivo de su salud mental y confusin general y/o estupor a quienes inicialmente se les administr citicolina durante 5 o 10 das (2,000 mg/da, por infusin intravenosa) dentro de un perodo de cuatro meses, y luego durante 21 das (1,000 mg/da, por inyeccin intramuscular), repetido una vez despus de un perodo de lavado de siete das (93)

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In addition, APIJNS exhibits efficient CAT-like activity, which can catalyze the production of O 2 from overexpressed H 2 O 2 in TME, which not only alleviates the hypoxia within the tumor lesion, but also converts it into 1 O 2 to activate the photosensitizer ICG and enhance the effect of PDT for synergistic antitumor effects

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Its chemical structure is not rapidly degraded by enzymes and gastric conditions in the laboratory, and thus provides a much more stable and resilient target sequence for testing on protocols for soft tissue regeneration

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