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Loss of redox balance further constrains glutathione synthesis and recycling, magnifying cellular vulnerability

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With the production of adipokines and decreased activity of GPx and antioxidant capacity, the endothelium becomes deficient in nitric oxide (NO), a vasodilator, and thus promotes atherosclerotic diseases

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The stimulation of IL-6 results in a lower collagen content, which further promotes matrix metalloproteinase (MMP) production (Huang et al