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Downregulation of HDAC3 activates cholesterol synthesis in gastric cancer cells, which induces ROS production, thereby inducing oxidative stress and apoptosis

Paired samples for histological efficacy were available from 211 patients (72 on placebo, 66 and 73 on lanifibranor 800 and 1200 mg)

Two slides were prepared with immunohistochemical evaluation of proliferative activity following treatment via placing them on a positively charged slide (Optiplus, Biogenex, USA) and immunostained using the three-step indirect streptavidin method [16] for Monoclonal Mouse Anti-Human Ki-67 Antigen (MIB-1), clone M 7240, (DAKO, Denmark)

MSC-Exos targets ferroptosis in neurodegenerative diseases Neurodegenerative disorders represent a category of incurable diseases manifesting as a slow deterioration in cognitive function, which notably impacts the quality of life for patients [107]

doi: 10.1111/j.1749-6632.2002.tb04690.x

CXCL13 and S1P) were unchanged in Gclc -deficient mice when compared to control littermates (Supplementary Fig