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It inhibits melanin production, reducing the appearance of dark spots, hyperpigmentation, and other skin discolorations, leading to a brighter and more even complexion

-sitosterol protects against lithocholic acid-induced hepatotoxicity and cholestasis via farnesoid X receptor-mediated regulation of transporters and enzymes in vitro and in vivo

In this context, however, the thiol antioxidant glutathione (GSH) represents a dominant defence system with the capacity to neutralize a broad range of both ROS and RNS [39]

Funding The authors declare that no financial support was received for the research and/or publication of this article

Due to this, the demand for glutathione is growing in the pharmaceutical and cosmetic industries

In summary, SGI-110, as a prodrug for decitabine, could release decitabine slowly and has a longer exposure window (Issa et al., 2015)