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Although there is a broad clinical spectrum of glutathione synthetase deficiency, manifestations usually include hemolytic anemia, often include metabolic acidosis, and sometimes include progressive neurologic symptoms as well as other systemic signs (eg, respiratory distress, sepsis, hyperbilirubinemia) (62

Stockwells lab in Columbia University report that the gene expression of CHAC1, PTGS2, SLC7A11 , and ACSL4 was induced during ferroptosis, and their upregulation detected by qPCR can be regarded as an indicator of ferroptosis (Dixon, Patel et al., 2014, Stockwell, 2022)

It helps in replenishing fluids and vitamins quickly rather than the traditional ways that may take several hours

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This nuanced understanding also speaks to the metabolic flexibility of immune cells and further highlights the need to continue to define compensatory metabolic responses engaged upon primary pathway inhibition or blockade