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Of note, C1-27 inhibited the clonogenic survival of HCT116 cells at sub-micromolar concentrations (Fig

However, the general erythrogram parameters of calves indicate that they were not in an anemic state, since there was no decrease in plasma hemoglobin and other parameters such as mean corpuscular volume and mean corpuscular hemoglobin remained within normal values

Studies such as VARSITY show that it has a higher endoscopic remission rate in UC compared to adalimumab, and similar efficacy in CD, making it suitable for patients with anti-TNF failure or intolerance [323]

In light of these findings, SHMT has garnered significant attention as a promising therapeutic target