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Notably, microbial imprinting in the respiratory epithelium may dynamically regulate future immune responses by modulating cytokine output such as IL-1b and IL-8 (149), resembling the trained immunity seen in macrophages

The speed of this collateral activation appears rapid compared to natural compensatory processes

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Biowaivers: In certain cases, such as highly soluble, high-permeability drugs, an in vivo BE study may be waived, relying on in vitro dissolution testing instead

Killion JJ, Dunn JD

Autosomal recessive congenital sensorineural hearing loss due to a novel compound heterozygous PTPRQ mutation in a Chinese family