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doi: 10.3389/fcell.2019.00189 22 LongF

So, it becomes a vicious cycle of the supply having a harder time to meet the growing demand as we age

10.1111/j.1532-5415.2010.02906.x 69

Additionally, certain lipoxygenases (LOXs) can directly oxidize PUFAs in biological membranes, mediating lipid peroxidation [7]

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systematically reviewed the oxidative stress from the perspectives of oxidants and antioxidants, and noted that oxidants with vastly different half-lives may be observed at the site of generation or be transported to distant target sites where they exert oxidant activities in cell metabolism [63]