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The proposed GND combination (guanfacine, NAC, donepezil) leverages distinct and complementary mechanisms of action, with minimal risk of drugdrug interactions, offering a comprehensive and well-tolerated therapeutic strategy for addressing the complex and chronic neurocognitive sequelae of sTBI (Figure 1)

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All data were normalized to -actin and GAPDH expression and are given relative to control (control=1, not shown in figure)