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Extracellular HSP27 also induces VEGF-A release from monocytes, the upstream signal of the angiogenic program that years of consistent heat exposure can produce structurally (HSP Immune Network review 2021)

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Preclinical studies have explored its involvement in repair processes, vascular adaptation, and inflammatory regulation, positioning it as a molecule of interest in musculoskeletal and gastrointestinal research contexts (1)