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Response: We acknowledge the commenters' recommendation to implement the proposed cost measure exclusion policy earlier than we proposed

It also has a role in producing red blood cells, as well as sex- and stress-related hormones

This can lead to B12 deficiency, which can cause many symptoms such as numbness, weakness, abnormal gait, memory loss, depression, and anemia among many others (No Stomach for Cancer, 2023)

The following protocols represent common clinical strategies, though individual optimization should involve healthcare provider guidance

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Initially, higher doses may be given more frequently (e.g., weekly or monthly), followed by maintenance doses to keep B12 levels stable