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TDP-43 TDP-43 has a multiple-domain structure consisting of an NTD that mediates weak self-interactions 72,73 , two RRMs, an intrinsically disordered CTD that mediates heterotypic interactions with binding partners using glycine-rich LCD, and helix-helix contacts for self-assembly by LLPS 74,75

Y., Saito, M., Kato, H., Morikawa, K., Kikukawa, H., Nomura, H., et al

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Notably, activated PRP appeared to produce more favorable outcomes, whereas non-activated PRP was associated with a higher incidence of adverse effects [32]

Asghar, U., Witkiewicz, A

Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology