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Further research has revealed that KLF2 can bind to the promoter of GPX4 in ccRCC, leading to the downregulation of GPX4 expression, which protects ccRCC cells from ferroptosis, thus promoting tumor cell metastasis (255)

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Enzyme-based creatinine sensing typically follows one of two biochemical pathways [188]

Protein unfolding was measured by detecting the temperature-dependent change in tryptophan fluorescence at emission wavelengths of 330 and 350 nm

These results suggest that -KG insufficiency induces disulfide stress accumulation and sensitizes human liver and lung cancer cells to glucose starvation

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