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Many patients report continued enhancements for up to a year post-procedure

Keap1, a regulatory protein that normally sequesters Nrf2 in the cytoplasm, releases it under oxidative stress conditions, enabling Nrf2 to bind to AREs and initiate gene transcription

CRISPR guide RNAs were designed using CHIRPOR.org 42 and were used as two-part synthetic crRNA and tracrRNA (Alt-RTM CRISPR guide RNA, Integrated DNA Technologies, Inc)