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Particularly for those with a family history or genetic predisposition (like APOE4 carriers for AD), microbiome-based prevention could be an attractive low-risk strategy to reduce risk or delay onset

The extreme version, from the pure carnivore diet types, is that plants are trying to kill us

In cases of diagnostic uncertainty, additional tests such as holotranscobalamin or methylmalonic acid may be considered

Development of an individualized treatment plan based on functional goals may assist to maximize patient outcomes

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A meta-analysis of four observational studies, following a total of 7,475 older individuals for 3 to 16 years, found a weak association between an elevation in vitamin B 12 of 50 pmol/L in blood and a reduction in fracture risk (114)