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Chronic adaptations require 4-8 week protocols, while tissue remodelling studies may extend 12+ weeks

Along with a change in the profile of sulfur-containing metabolites, in cells that have lost ADP-heptosis, an increase in the level of generation of reactive oxygen species (ROS) is observed, accompanied by the depletion of NADPH reducing equivalents

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As demonstrated, silencing either EAAT3 or P65 led to the accumulation of ROS (Fig