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To compare AfCycDesign-generated sequences to sequences designed by ProteinMPNN, we we also designed sequences of 22,182 10 residue hallucinated backbones using ProteinMPNN 32 and compared the pLDDT of peptides designed by both methods (Supplementary Fig

A good example of this is given by flutamide, an antiandrogen used in the treatment of prostatic carcinoma, which undergoes substantial metabolism in vivo with hydrolysis of the amide bond liberating 3-trifluoromethyl-4-nitroaniline

Virus-shaped mesoporous silica nanostars to improve the transport of drugs across the blood-brain barrier

Fenton, J

Chitosan also increases the hydrophilicity of the nanoparticles, which contributes to the enhancement of the NP stability in the aqueous environment

Up-regulation of heme oxygenase-1 expression and inhibition of disease-associated features by cannabidiol in vascular smooth muscle cells