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If you cannot answer those, the comparison is academic

In addition, many sexual enhancement supplements have been found to contain undeclared sildenafil and tadalafil, so that taking them along with the same prescribed medications for erectile dysfunction may result in too large a dose and an increase in side-effects associated with these drugs (see the list of Recalls and Warning s for supplements found to contain these drugs)

These challenges have driven research into alternative delivery methods

Appraising the entourage effect: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer

May 2015;10(5):808-13

Initial assessment and diagnosis: Patients concerned about B12 deficiency should first consult their GP