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Although M2 macrophages have been studied for their central role in fibrosis and cell proliferation during tissue repair [42, 49], our study provides strong evidence, which was previously unidentified, that they may also have a promoting effect on myofibroblast differentiation of LR-MSCs

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Furthermore, the impact of mental health disorders should be assessed individually as opposed to using the non-specific outcome of common mental disorders. At the same time, there is a need for new biochemical studies to investigate how UPFs affect key pathophysiological pathways involved in the development of mental disorders, particularly how lipid dysregulation and changes in specific lipid species contribute to heightened levels of neuroinflammation and altered neurotransmission