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Furthermore, we examine the opposing roles of CHAC1 and CHAC2 in stem cell fate decisions via NOTCH1 signaling and development

We confirmed an increase in ER stress markers, including ATF3, and a decrease in LAMP2A expression in NASH livers induced by MCD or CDHFD in mice

Wang Y, Jain P, Locke FL, Maurer MJ, Frank MJ, Munoz JL, Dahiya S, Beitinjaneh AM, Jacobs MT, Mcguirk JP, Vose JM, Goy A, Andreadis C, Hill BT, Dorritie KA, Oluwole OO, Deol A, Paludo J, Shah B, Wang T, Banerjee R, Miklos DB, Rapoport AP, Lekakis L, Ghobadi A, Neelapu SS, Lin Y, Wang ML , Jain MD

Its small molecular size and amphiphilic properties (able to be dissolved in both fat and water) allow this molecule to penetrate all cells and cellular compartments, most notably the mitochondria

Various research groups subsequently documented a large number of SBs